D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist. It has a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels, and presents an atypical antipsychotic profile.
- Selective dopamine D3 receptor and 5-HT2A receptor antagonist.
- Partial 5-HT1A receptor agonist.
- Shows Ki values of 4.5 nM (D3), 11.9 nM (5-HT2A), and 15.3 nM (5-HT2A).
- Low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels.
- Atypical antipsychotic profile.